PDF] Fast Mimicking of Phase 1 and 2 Metabolism of Acetaminophen using the ROXY EC System difference Semantic Scholar Conjugation With Glutathione and Mercapturic Acid Formation Biotransformation of Drugs A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body STUDENT CONSULT (ver. 2.3)