Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums